Macrocyclic compounds useful as inhibitors of kinases and hsp90

Details Macrocyclic compounds useful as inhibitors of kinases and hsp90 Macrocyclic compounds useful as inhibitors of kinases and hsp90

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/365 (2006.01) A61K 31/4427 (2006.01) C07D 407/10 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2696021

Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.

L'invention concerne des composés macrocycliques répondant aux formules I-V, lesquels sont des analogues des lactones de l'acide résorcylique et de pochonine; et des procédés pour la préparation des composés. Les composés de la présente invention sont utiles en tant qu'inhibiteurs de kinases et de la protéine de choc thermique 90 (HSP90). L'invention concerne également des compositions pharmaceutiques comprenant une quantité efficace des composés inhibant les kinases ou inhibant la HSP90; et des procédés pour le traitement de troubles faisant intervenir des kinases et la HSP90.

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