C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/18 (2006.01) A61K 31/40 (2006.01) A61K 31/70 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01)
Patent
CA 2204739
This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating <u>Actinoplanes</u> sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocyclic lactone compound from the fermentation broth. The compounds produced by this process include a compound of formula (I). The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.
La présente invention concerne un procédé de production d'un composé lactone macrocyclique. Ce procédé consiste à mettre l'espèce <u>Actinoplanes</u> (FERM BP-3832) en culture en présence de L-proline, L-hydroxyproline ou d'acide L-nipécotique, puis à isoler un composé lactone macrocyclique du bouillon de fermentation. Les composés obtenus selon ce procédé comprennent un composé représenté par la formule générale (I). L'invention concerne également une composition pharmaceutique comprenant ce composé, laquelle composition pharmaceutique s'utilise avantageusement notamment comme agent immunodépresseur, antimycosique ou antitumoral.
Inagaki Taisuke
Kojima Nakao
Kojima Yasuhiro
Nishida Hiroyuki
Yamauchi Yuji
Limited Pfizer
Smart & Biggar
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