C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/42 (2006.01) A61K 31/16 (2006.01) A61K 47/48 (2006.01) C08G 69/48 (2006.01) C08G 73/02 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2671900
Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.
L'invention concerne des agents bioactifs comprenant un composé qui inhibe l'activité de transport ionique d'un régulateur de la perméabilité transmembranaire de la fibrose kystique (CFTR) et qui est lié à une macromolécule qui a une interaction avec une cellule qui exprime le CFTR. Les agents bioactifs de l'invention sont utiles dans le traitement de maladies, troubles et séquelles de maladies, pathologies et états qui sont associés à l'activité du CFTR accrue de façon aberrante, par exemple, la diarrhée sécrétoire.
Sonawane Nitin D.
Verkman Alan S.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Regents Of The University Of California
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