C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 5/00 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07D 257/02 (2006.01) C07D 413/06 (2006.01) C07D 417/14 (2006.01) C07F 1/08 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01)
Patent
CA 2065415
ABSTRACT OF THE DISCLOSURE Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with a m i n o a 1 k y 1 a m i d e d e r i v a t i v e s o f diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetraacetic acid ("EDTA") or other polyaminocarboxylic or cyclic polyaminocarboxylic chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.
Periasamy Muthunadar P.
Rajagopalan Raghavan
Mallinckrodt Inc.
Osler Hoskin & Harcourt Llp
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