Malonamide derivatives with antithrombotic activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/30 (2006.01) A61K 31/44 (2006.01) A61P 7/00 (2006.01) C07C 15/00 (2006.01) C07D 211/42 (2006.01) C07D 213/34 (2006.01) C07D 213/80 (2006.01) C07D 309/08 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2693396

The present invention relates to compounds of the formula (I). The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VI1a and can in general be applied in conditions in which an undesired activity of factor VI1a is present or for the cure or prevention of which an inhibition of factor VI1a is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

La présente invention porte sur des composés de la formule (I). Les composés de la formule I sont des composés pharmacologiquement actifs de valeurs qui présentent un fort effet antithrombotique et sont appropriés, par exemple, pour la thérapie et la prophylaxie de troubles cardio-vasculaires comme les maladies thromboemboliques ou les resténoses. Lesdits composés sont des inhibiteurs des enzymes de la coagulation du sang, notamment du facteur VIIa et peuvent en général être appliqués dans des états présentant une activité non souhaitée du facteur VIIa ou dans des états pour la guérison ou la prévention desquelles une inhibition d'un facteur VIIa est souhaitable. L'invention porte, de plus, sur des procédés de préparation de composés de la formule (I), sur leur utilisation, en particulier en tant que principes actifs dans des produits pharmaceutiques, et sur des préparations pharmaceutiques les comprenant.

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