Manganese complexes of nitrogen-containing macrocyclic...

Details Manganese complexes of nitrogen-containing macrocyclic... Manganese complexes of nitrogen-containing macrocyclic...

A - Human Necessities

61

K

A61K 31/555 (2006.01) C07D 259/00 (2006.01) C07F 13/00 (2006.01)

Patent

CA 2151262

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4 R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, R10 and R'10, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.

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