C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2692909
The present invention provides 27 marker genes comprising Orm1, Scarb1, Stmn1, Rad21, Nup54, Jun, Dmp1, Abi1, 6530403A03Rik, Slc2a1, Plf (Plf2, Mrpp1f3), Fosll, Chekl, Pik3r5, JunB, Vegfa, Rif1 (LOC671598), Illrl1, Phex, Tfrc, Zfhx1b, Rad51ap1, Hells, Mcm3, Orm2, Car13 and Ccnb1, which enables the detection of a tumor promoter in a simple manner and within a short period of time in a test for predicting carcinogenicity as a tumor promoter using a cultured cell. The present invention further provide a tumor promoter detection method using at least one of the marker genes.
L'invention concerne les 27 gènes marqueurs suivants : Orm1, Scarb1, Stmn1, Rad21, Nup54, Jun, Dmp1, Abi1, 6530403A03Rik, Slc2a1, Plf (Plf2, Mrpplf3), Fosl1, Chek1, Pik3r5, Junb, Vegfa, Rif1 (LOC671598), Il1rl1, Phex, Tfrc, Zfhx1b, Rad51ap1, Hells, Mcm3, Orm2, Car13 et Ccnb1. Ces marqueurs permettent de détecter un promoteur de tumeur d'une manière simple et rapide dans le test de prédiction de la cancérogénicité d'un promoteur de tumeur au moyen de cellules en culture. L'invention décrit également un procédé de détection de promoteur utilisant l'un quelconque des gènes marqueurs.
Maeshima Hideki
Ohno Katsutoshi
Yamada Toshihiro
Marks & Clerk
Nissin Foods Holdings Co. Ltd.
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