Medical implants and methods of making medical implants

A - Human Necessities – 61 – L

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61L 31/08 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2748273

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio- absorbable polymer and/ or pharmaceutical agent is deposited over the bioactive agent.

La présente invention concerne un implant médical comportant un substrat avec une surface oxydée, un revêtement de dérivé de silane lié de façon covalente à la surface, et un agent bioactif lié de façon covalente au revêtement. L'invention concerne aussi un stent implantable comprenant un cur de stent avec une surface oxydée recouverte d'une couche de dérivé de silane liée de façon covalente à la surface, une couche d'espacement comprenant du polyéthylène glycol (PEG) liée de façon covalente à la couche de dérivé de silane, et une protéine liée de façon covalente au PEG. L'invention concerne aussi un procédé de fabrication d'un implant médical qui consiste à obtenir un substrat comportant une surface, oxyder cette surface et la faire réagir avec un silane dérivé pour former un revêtement de silane lié de façon covalente à la surface, puis lier de façon covalente un agent bioactif au revêtement de silane. Dans des cas particuliers, un revêtement supplémentaire de polymère et/ou d'agent pharmaceutique bioabsorbables est déposé sur l'agent bioactif.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Medical implants and methods of making medical implants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Medical implants and methods of making medical implants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Medical implants and methods of making medical implants will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1990052

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.