C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 38/19 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C12N 15/19 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2073177
62 ABSTRACT OF THE DISCLOSURE Disclosed is a novel, substantially pure megakary- ocyte potentiator protein having the activity to pro- mote the proliferation and differentiation of a mega- karyocyte and which has: a molecular weight of 25,000 + 8,000 as measured by gel filtration; an isoelectric point of 8 + 1 as measured by isoelectric focusing; a different immunogenicity from those of human erythro- poietin, human interleukin 1.alpha., human interleukin 1.beta., human interleukin 6 and human interleukin 7; and no megakaryocyte colony stimulating factor activity. The megakaryocyte potentiator of the present invention can be prepared by cell culturing or genetic engineering techniques. Since the megakaryocyte potentiator pro- tein of the present invention has not only the activity to promote the proliferation and differentiation of a megakaryocyte but also the activity to promote the production of platelets in peripheral blood, it can be used for the prevention and treatment of thrombocytope- nia and the like.
Kondo Shuhei
Ogawa Kohei
Asahi Kasei Kogyo Kabushiki Kaisha
Goudreau Gage Dubuc
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