Melphalan derivatives

Details Melphalan derivatives Melphalan derivatives

A - Human Necessities

61

K

167/129, 167/233

A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1284507

ABSTRACT A compound of formula I Image Formula I wherein R1 is of formula II Image Formula II wherein R4 and R5 , which may be the same or different, are bromo, chloro, iodo or alkylsulphonyl: R2 is of formula III Image Formula III wherein R6 and R7 , which may be the same or different, are H, alkyl, aryl, carboxy, hydroxy or amino and n is 0-10; and R is hydroxy or a group capable of being cleared and replaced by a radical having an antigen binding site or is a radical having an antigen binding site. Compounds of the present invention are useful as antitumor agents.

526567

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