C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2283476
This invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.
La présente invention concerne la découverte d'un nouveau gène suppresseur de tumeur associé à une adénomatose polyendocrinienne de type 1. Le gène est appelé MEN1 et le produit génique est une ménine. L'absence de cette protéine et des mutations associées dans le gène correspondant ont été identifiées dans des individus souffrant d'adénomatose polyendocrinienne type 1. L'identification de ce marqueur pour une adénomatose polyendocrinienne de type 1 est utilisé dans des diagnostics ainsi que pour une thérapie gènique.
Agarwal Sunita K.
Burns A. Lee
Chandrasekharappa Settara C.
Collins Francis S.
Debelenko Larisa V.
Fetherstonhaugh & Co.
The Government Of The United States Of America Reprsented By The Secret Ary Of The Department Of Health And Hum
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