C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/209, 260/237
C07D 519/04 (2006.01) A61K 31/475 (2006.01) A61K 47/26 (2006.01)
Patent
CA 1272192
23305-1029(S) ABSTRACT The invention relates to new aqueous pharmaceutical compositions containing as active ingredient a pharmaceutically acceptable complex of a bis-indole compound with a bi- or multi- valent metal ion in a therapeutically effective amount. The in- vention further relates to complexes formed between a bis-indole compound and a bi- or multivalent metal ion of the formula (I): Image (1) According to another aspect of the invention there is provided a process for the preparation of a pharmaceutically acceptable metal complex of a bis-indole compound and optionally stable aqueous pharmaceutical compositions containing said metal complex, in which a solution of a bis-indole compound or a phar- maceutically acceptable salt thereof in an aqueous medium is reacted with a non-toxic water soluble salt of a bi- or multi- valent metal capable of complexation, at a pH of 3.0 to 6.0, optionally in the presence of or followed by the addition of a conventional pharmaceutical carrier and/or further additive, or, 23305-1029(S) if desired, the obtained complex is isolated. The aqueous pharmaceutical compositions according to the invention have substantially increased stability.
492974
Burger Kalman
Gazdag Maria
Nagy Geza Takacsi
Nee Sziklay Pap Zsofia
Szepesi Gabor
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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