Metal complexes of n-methyl-11-aza-10-deoxo-10-...

Details Metal complexes of n-methyl-11-aza-10-deoxo-10-... Metal complexes of n-methyl-11-aza-10-deoxo-10-...

C - Chemistry, Metallurgy

07

H

167/119, 167/185

C07H 17/08 (2006.01) C07H 17/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1303028

ABSTRACT New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydro- erythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu+2, Zn 2, Co+2, Ni+2 and Ca+2, a process for their manufacture and their use in the manufacture of antibiotically active pharmaceuticals. New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydro- erythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu+2, Zn+2, Co+2, Ni+2 and Ca+2 are made by reacting N-methyl-11-aza- 10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydro- erythromycin A in its free base form or in its water-soluble salt form with salts of said bivalent metals. The compounds possess antibiotic activity.

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