C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 14/575 (2006.01) C07K 14/61 (2006.01) C07K 14/72 (2006.01) C12N 15/16 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2087267
2087267 9203478 PCTABS00010 Novel methods are disclosed for modulating the action of polypeptide hormones on mammalian cells, organs or whole mammals. Polypeptide hormone action is controlled by effecting the binding specificity of the polypeptide hormone for distinct receptors. The specificity for the receptor is mediated by the ability of a metal ion to complex between the polypeptide hormone and its receptor. Soluble variants of the hormone receptor may be used to modulate the action or serum half-life of the complexed polypeptide hormone. An example of such a polypeptide hormone system is human growth hormone (hGH) wherein receptor specificity is modulated by the metal cofactor zinc. Under low zinc conditions, hGH preferentially binds to human growth hormone receptor or binding protein, under high zinc conditions, hGH preferentially binds to human prolactin receptor or soluble prolactin receptor variants. This is the first indication that a metal ion can mediate a direct interaction between a polypeptide hormone and an extracellular receptor or binding protein.
Bass Steven H.
Cunningham Brian C.
Fuh Germaine
Lowman Henry B.
Matthews David J.
Genentech Inc.
Johnson Douglas S. Q.c.
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