Metallo-.beta.-lactamase inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 57/13 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) A61P 31/04 (2006.01) C07C 57/26 (2006.01) C07C 57/42 (2006.01) C07C 57/48 (2006.01) C07C 57/50 (2006.01) C07C 59/42 (2006.01) C07C 59/46 (2006.01) C07C 59/52 (2006.01) C07C 59/60 (2006.01) C07C 59/68 (2006.01) C07C 65/00 (2006.01) C07C 69/60 (2006.01) C07C 69/618 (2006.01) C07C 69/675 (2006.01) C07C 69/736 (2006.01) C07C 217/22 (2006.01) C07C 233/65 (2006.01) C07C 235/06 (2006.01) C07C 237/06 (2006.01) C07C 279/08 (2006.01) C07C 323/54 (2006.01)

Patent

CA 2620675

Disclosed is a metallo-.beta.-lactamase inhibitor which can inactivate a .beta.-lactam antibiotic and recover the anti-bacterial activity of the .beta.- lactam antibiotic. A maleic acid derivative having a structure of the general formula (I) has an inhibitory activity against metallo-.beta.-lactamase. The use of the compound (I) in combination with a .beta.-lactam antibiotic enables to recover the anti-bacterial activity of the .beta.-lactam antibiotic against a bacterium capable of producing mettalo-.beta.-lactamase.

La présente invention concerne un inhibiteur de la métallo-pénicillinase, enzyme capable d'inactiver une bêtalactamine antibiotique, l'inhibition de la métallo-pénicillinase permettant de récupérer l'activité antibactérienne de la bêtalactamine antibiotique. L'invention concerne un dérivé de l'acide maléique dont la structure est représentée par la formule générale (I) et qui possède une activité inhibitrice contre la métallo-pénicillinase. L'utilisation du composé (I) en combinaison avec une bêtalactamine antibiotique permet de récupérer l'activité antibactérienne de la bêtalactamine antibiotique pour lutter contre une bactérie capable de produire de la métallo-pénicillinase.

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