Method and compositions for identifying anti-hiv therapeutic...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/44 (2006.01)

Patent

CA 2550730

Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

L'invention concerne des méthodes permettant d'identifier des composés thérapeutiques anti-VIH substitués par des groupes d'ester de phosphonate ou d'ester de carboxyle. Des bibliothèques de tels composés sont criblées, facultativement, au moyen de la nouvelle ester hydrolase GS-7340 enzymatique. Ladite invention a également trait à des compositions et à des méthodes liées à l'ester hydrolase GS-7340.

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