C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/44 (2006.01)
Patent
CA 2550730
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
L'invention concerne des méthodes permettant d'identifier des composés thérapeutiques anti-VIH substitués par des groupes d'ester de phosphonate ou d'ester de carboxyle. Des bibliothèques de tels composés sont criblées, facultativement, au moyen de la nouvelle ester hydrolase GS-7340 enzymatique. Ladite invention a également trait à des compositions et à des méthodes liées à l'ester hydrolase GS-7340.
Arimilli Murty N.
Becker Mark M.
Birkus Gabriel
Bryant Clifford
Chen James M.
Gilead Sciences Inc.
Robic
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