Method and compounds

C - Chemistry – Metallurgy – 07 – C

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C07C 279/28 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01) A61K 31/275 (2006.01) C07C 335/16 (2006.01) C07C 335/22 (2006.01)

Patent

CA 2014196

B2718/Abs Abstract NOVEL METHOD AND COMPOUNDS A method for the treatment of disorders of the respiratory system and/or for the treatment of cerebrovascular disorders and/or neuronal degenerative disorders which method comprises the administration, to a human or non-human mammal in need of such treatment, of an effective, non-toxic amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof: Image ( I ) wherein: R1 is an aryl group substituted with up to three substituents selected from the group consisting of: CN, NO2, CF3, halogen, C2-12 alkyl and C2-12 alkyl carbonyl; R2 is S or NCN; and R3 is an alkyI group or an aryl group; certain compounds having pharmacological activity, a process to prepare such compounds and pharmaceutical compositions comprising such compounds.

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