Method for detecting il-16 activity and modulation of il-16...

Details Method for detecting il-16 activity and modulation of il-16... Method for detecting il-16 activity and modulation of il-16...

G - Physics

01

N

G01N 33/567 (2006.01) G01N 33/53 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2655471

Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of or susceptibility of a subject to an IL-16-related disorder involve measuring and comparing the levels of RANTES proxy produced by eukaryotic cells, such as CD4+ and CD9+ cell lines, peripheral blood mononuclear cells, HuT-78 cells, and/or THP-1 cells.

La présente invention concerne des procédés destinés à détecter l'activité biologique de l'IL-16, à détecter la modulation de l'activité biologique de l'IL-16, et à diagnostiquer la présence d'un trouble associé à l'IL-16 chez un sujet ou la sensibilité d'un sujet audit trouble, le procédé impliquant la mesure et la comparaison des niveaux de RANTES produits par des cellules eucaryotes, telles que les lignées cellulaires CD4+ et CD9+, les cellules mononucléaires sanguines périphériques, les cellules HuT-78 et/ou les cellules THP-1.

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