Method for enhancing the presentation of exogenous antigen...

Details Method for enhancing the presentation of exogenous antigen... Method for enhancing the presentation of exogenous antigen...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2397729

The invention relates to an opsonized micro-particle complex comprising: a micro-particular vector encapsulating at least one antigen, and at least one antibody or fragment thereof, with said antibody being a human or humanized antibody or an antibody binding to human FcR with substantially the same affinity and avidity as the ones of a human antibody and with said antibody or fragment thereof having the carboxy terminal end of its Fc portion external with respect to the opsonized micro particle complex.

L'invention porte sur un complexe de microparticules opsonisées comprenant un vecteur microparticulaire encapsulant au moins un antigène, et au moins un anticorps ou un fragment de celui-ci, cet anticorps étant un anticorps humain ou humanisé ou un anticorps se liant à un FcR humain ayant pratiquement la même affinité et avidité que celles d'un anticorps humain, et se liant également à l'anticorps ou au fragment de celui-ci possédant la terminaison carboxy de sa partie Fc externe par rapport au complexe de microparticules opsonisées.

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