C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
195/1.12, 150/8.
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C25C 1/20 (2006.01) C25C 7/00 (2006.01)
Patent
CA 1339206
A process for determining the genotype of an individual with respect to the alleles at the HLA DP locus involves obtaining a sample of nucleic acid from the individual and hybridizing the nucleic acids with a panel of probes specific for variant segments of DPalpha and DPbeta genes. Because the variation between DPbeta alleles is highlydispersed throughout the second exon of the DPbeta gene, the discovery of many different DPbeta alleles makes the process far more discriminating and informative than cellular, RFLP, or serological methods. The process can also be carried out on amplified nucleic acid produced by the polymerase chain reaction using primers specific for the second exon of the DPalpha and DPbeta genes. HLA DP DNA typing methods are useful in the prevention of graft rejection and host versus graft disease, in determining susceptibility to autoimmune diseases, in providing evidence concerning the derivation from an individual of forensic samples, and in paternity testing.
600226
Begovich Ann B.
Bugawan Teodorica L.
Erlich Henry A.
Horn Glenn T.
Begovich Ann B.
Borden Ladner Gervais Llp
Bugawan Teodorica L.
Erlich Henry A.
F. Hoffmann-La Roche Ag
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