Method for identifying and selecting drug candidates for...

G - Physics – 01 – N

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G01N 33/50 (2006.01) C04B 20/06 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2739476

A method for identifying and selecting chemical entities that contributes to a functional effect in the development of new combinatorial drugs. The combinations of two or more chemical compounds show a synergistic effect. The compounds can be e.g. antibodies, antibiotics, anti-cancer agents, anti-AIDS agents, anti- growth factors, antiviral agents, soluble receptors, cytokines, RNAi's, vaccines and mixtures thereof. The method comprises a) providing n samples each comprising a chemical entity, b) mixing 2 or more of the n samples in all possible combinations, c) subjecting this mixture to a functional assay in order to identify entities contributing to the functional effect. The steps a-c are repeated on the chemical entities from step c which contribute to the functional effect.

La présente invention concerne un procédé didentification et de sélection dentités chimiques qui contribuent à un effet fonctionnel dans le développement de nouveaux médicaments combinatoires. Les combinaisons de deux composés chimiques ou plus présentent un effet synergique. Les composés peuvent par exemple être des anticorps, des antibiotiques, des agents anticancéreux, des agents anti-SIDA, des facteurs anti-croissance, des agents antiviraux, des récepteurs solubles, des cytokines, des ARNi, des vaccins et des mélanges de ceux-ci. Le procédé comprend a) la fourniture de n échantillons comprenant chacun une entité chimique, b) le mélange de deux ou plus des n échantillons dans toutes les combinaisons possibles, c) la soumission de ce mélange à un essai fonctionnel de manière à identifier des entités qui contribuent à leffet fonctionnel. Les étapes a à c sont répétées sur les entités chimiques de létape c qui contribuent à leffet fonctionnel.

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