Method for inhibiting or treating a disease associated with...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/10 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2659032

A therapeutic agent which carries a peptide sequence containing a mammalian cell adhesion sequence can be used to inhibit or treat diseases associated with intracellular formation of protein fibrillar inclusions or aggregates, to inhibit the intracellular formation of protein fibrillar inclusions or aggregates, and to disaggregate pre-formed intracellular protein fibrillar inclusions or aggregates. Filamentous bacteriophage which displays a non-filamentous bacteriophage RGD cell adhesion sequence on its surface, but not an antibody or non-filamentous bacteriophage antigen other than said RGD cell adhesion sequence, is a preferred embodiment of such a therapeutic agent.

La présente invention concerne un agent thérapeutique qui comporte une séquence peptidique contenant une séquence d'adhérence de cellule mammalienne et peut être utilisé pour inhiber ou traiter des maladies associées à la formation intracellulaire d'inclusions ou d'agrégats fibrillaires protéiques, pour inhiber la formation intracellulaire d'inclusions ou d'agrégats fibrillaires protéiques, et pour désagréger les inclusions ou les agrégats fibrillaires protéiques intracellulaires préformés. Un mode de réalisation préféré d'un tel agent thérapeutique porte sur un bactériophage filamenteux qui présente une séquence d'adhérence cellulaire RGD de bactériophage non filamenteux à sa surface, mais pas un anticorps ou un antigène de bactériophage non filamenteux différent de ladite séquence d'adhérence cellulaire RGD.

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