C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
167/103, 195/33,
C08F 220/02 (2006.01) C08F 8/32 (2006.01)
Patent
CA 1059694
ABSTRACT OF THE DISCLOSURE The present invention relates to a method of manufactur- ing a macromolecular form of active substances with -NH2 groups which is useful for protracted release of the active component by an enzymatic cleavage, wherein an N-substituted amide or ester of acrylic or methacrylic acid, which contains at least three chained atoms in its side chain terminated by the carboxylic car- bon atom, is condensed with the.alpha.-amine group of an aminoacid of L-configuration, as .beta.-phenylalanine, tyrosine, tryptophan, lysine, arginine, glycine, alanine, leucine, citrulline or ornithine, and then an active component is bonded by its -NH2 groups to the car- boxylic group of this amino acid and the resulting monomer is copolymerised with a hydrophilic monomeric component based on N-alkymethyacrylamide, N-alkyacrylamide, N,N-dialkylacrylamide where alkyl has 1 to 6 carbon atoms and may contain 1 to 3 -OH groups, or glycol methacrylate or glycol acrylate, where glycol is ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, triethylene glycol and tetraethylene glycol, alone or in a mixture, and if desired with further monomeric components which may act as crosslinking agent. The polymeric form prepared by the method according to the present invention enables to control the physical and biological fate of the active substance by the nature and molecular weight of the carrier-polymer.
229403
Drobnik Jaroslav
Exner Josef
Kalal Jaroslav
Kopecek Jindrich
Labsky Jiri
LandOfFree
Method for manufacturing of substances with -nh2 group which... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for manufacturing of substances with -nh2 group which..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for manufacturing of substances with -nh2 group which... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-578054