C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01)
Patent
CA 2347275
The invention relates to methods for measuring proteasome activity in biological samples. More particularly, the invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.
La présente invention concerne des procédés de mesure de l'activité de la protéasome dans des échantillons biologiques. Plus particulièrement, cette invention concerne des procédés de contrôle de l'effet médicamenteux suivant l'administration in vivo d'un inhibiteur de protéasome. Par ailleurs, cette invention concerne des procédés et des kits permettant de contrôler l'action médicamenteuse pharmacodynamique et de déterminer le dosage de l'inhibiteur de protéasome. Enfin, cette invention concerne des procédés de détermination de l'activité de départ de la protéasome chez un mammifère.
Adams Julian
Brand Stephen J.
Burns Dan R.
Chau Vincent
Dick Lawrence R.
Mbm Intellectual Property Law Llp
Millennium Pharmaceuticals Inc.
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