C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/179, 530/5.0
C07D 317/60 (2006.01) A61K 31/00 (2006.01) A61K 38/05 (2006.01) C07C 323/60 (2006.01) C07D 307/79 (2006.01) C07D 319/18 (2006.01) C07D 405/12 (2006.01) C07F 9/38 (2006.01) C07F 9/655 (2006.01) C07K 5/06 (2006.01)
Patent
CA 2039706
Amino acid drivatives, enkephalinase and ACE inhibitors, of the formula (1a) and (1b), wherein Rl represents a biphenyl group or one of the groups (a), wherein Z, Y and n have the meanings (b) or (c), wherein R'1, represents a hydrogen atom, a lower alkyl group; a phenyl group; a lower phenylalkylene group. R2 represents a hydrogen atom; a lower alkyl group; a lower hydroxyalkylene group; a lower phenylalkylene group; a lower hydroxyphenylalkylene group; a lower aminoalkylene group; a lower guanidinoalkylene group; a lower mercaptoalkylene group; a lower thioalkylene lower alkyl group; a lower imidazolylkylene group; a lower indolylalkylene group; a lower carbarnylalkylene group; a lower carboxyalkylene group or one of the groupings (d), where Z, Y and n have the meanings (e), X indicates a grouping responsible for chelating the zinc atom of enzymes, enkephalinase and ACE, and may be selected from the group which comprises a mercaptornethyl; hy- droxamic acid; an N-carboxyalkyl of the formula (f), wherein R3 represents a benzyl lower alkyl radical, or a benzyl lower alkoxy radical; phosphorus-containing derivatives of the formula (g) or (h).
Danvy Denis
Duhamel Lucette
Duhamel Pierre
Greciet Helene
Gros Claude
Fetherstonhaugh & Co.
Societe Civile Bioprojet
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