A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/08 (2006.01) A61J 1/00 (2006.01) A61J 3/00 (2006.01) A61M 5/00 (2006.01) A61M 5/28 (2006.01) A61M 5/315 (2006.01) A61J 1/06 (2006.01)
Patent
CA 2257904
The invention features a method comprising the following steps: preparing in a vacuum a dry form (18) of an active principle, as well as a liquid (22), and drawing this liquid into the dry form, by the action of the vacuum to obtain the injectable preparation. The device comprises a gastight syringe (19) to condition under vacuum the dry form (18), a reservoir (21) containing the liquid (22) and a cap (29) forming a connector between the syringe and the liquid reservoir, the injection needle (25) of the syringe being driven into the septum (24) of the cap (29). The invention enables a preparation which is directly injectable by means of an automatic rehydration step to be obtained; indeed, after activation, the extemporaneous preparation is automatic since the device elements move by themselves under the action of the liquid which is drawn by suction into the volume under vacuum containing the solid formulation (18).
Selon ce procédé, on prépare une forme sèche (18) d'un principe actif sous vide, ainsi qu'un liquide (22), et on introduit ce liquide dans la forme sèche par aspiration, grâce à l'action du vide pour former la préparation injectable; le dispositif comprend une seringue (19) étanche aux gaz pour conditionner sous vide la forme sèche (18), un réservoir (21) contenant le liquide (22) et un capuchon (29) formant connecteur entre la seringue et le réservoir de liquide, l'aiguille d'injection (25) de la seringue étant enfoncée dans le septum (24) du capuchon (29). L'invention permet d'obtenir la préparation directement injectable par une réhydratation automatique; en effet après activation, la préparation extemporanée est automatique car les éléments du dispositif se déplacent seuls sous l'action du liquide qui est attiré par aspiration dans le volume sous vide contenant la formulation solide (18).
Delab
Robic
Societe de Conseils de Recherches Et D'applications Scientifique
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