Method for preventing and treating hyperpermeability

Details Method for preventing and treating hyperpermeability Method for preventing and treating hyperpermeability

A - Human Necessities

61

K

A61K 38/19 (2006.01)

Patent

CA 2752890

A peptide is described, which consists of 7-17 adjacent amino acids and comprises the hexamer TX1EX2X3E, wherein X1, X2 and X3 can be any natural or non-natural amino acid, wherein the peptide has no TNF receptor binding activity and is cyclized, for the prevention and treatment of hyperpermeability of epithelial cells and endothelial cells.

L'invention concerne un peptide qui est constitué de 7-17 acides aminés voisins et comporte l'hexamère TX1EX2X3E, X1, X2 et X3 pouvant être tout acide aminé naturel ou non naturel, le peptide ne présentant aucune activité de liaison TNF-récepteur et étant cyclisé, pour empêcher et traiter l'hyperperméabilité de cellules épithéliales et de cellules endothéliales.

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