C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/56 (2006.01) A61K 38/04 (2006.01)
Patent
CA 2729188
The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotol-erance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers
La présente invention porte sur l'utilisation de macrocycles particuliers qui sont des inhibiteurs de la dégradation protéasomique de p27, en particulier de l'argyrine et de dérivés de celle-ci, pour un traitement dans diverses affections, telles que l'induction d'une immunotolérance, les maladies auto-immunes, les infections bactériennes et les maladies prolifératives, telles que les cancers.
Brodmann Tobias
Buelow Leila
Eggert Ulrike
Frank Ronald
Girbig Anna-Katharina
Gottfried Wilhelm Leibniz Universitaet Hannover
Heenan Blaikie Llp
Helmholtz-Zentrum Fuer Infektions-Forschung Gmbh
Medizinische Hochschule Hannover
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