Method for production of dimeric alkaloids

Details Method for production of dimeric alkaloids Method for production of dimeric alkaloids

C - Chemistry, Metallurgy

07

D

260/237.3

C07D 519/04 (2006.01)

Patent

CA 1334588

This invention concerns a method for the production of dimeric alkaloid, characterized by a procedure which comprises causing reaction of catharanthine with vindoline in the presence of Fe3+ and (1) removing or inactivating the Fe3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source. In accordance with this invention, such dimeric alkaloid as vinblastine, leurocidin, and 3',4'-anhydrovin- blastine which are useful as antineoplastic drugs can be produced in high yields.

607984

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