Method for the generation of genetically modified vertebrate...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/10 (2006.01) C12N 5/078 (2010.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 5/12 (2006.01) C12N 5/20 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2471392

The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymphoid lineage cells, and to the use thereof for the production of any heterologous antibody or binding protein.

La présente invention concerne généralement les domaines du génie génétique et de la production d'anticorps. Notamment, cette invention a trait à la génération de lymphocytes précurseurs de vertébrés génétiquement modifiés qui sont capables de se différencier en cellules de lignées lymphoïdes plus matures, ainsi qu'à l'utilisation associée pour la production de tout anticorps hétérologue ou de toute protéine de liaison.

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