Method for the optimization of chromatographic purification...

Details Method for the optimization of chromatographic purification... Method for the optimization of chromatographic purification...

B - Operations, Transporting

01

D

B01D 15/08 (2006.01) G01N 30/02 (2006.01)

Patent

CA 2655258

The invention relates to a process for finding suitable parameters for the chromatographic purification of biomolecules. The process consists of equilibration, loading, washing and elution steps, wherein this sequence of steps is carried out in the partial batch process. The parameters determined in small, preferably a plurality, of parallel batches give information on the chromatography conditions under which a given biomolecule may be optimally purified by column chromatography, if appropriate even on a relatively large scale.

L'invention concerne un procédé permettant de trouver des paramètres appropriés pour la purification chromatographique de biomolécules. Ce procédé comprend des étapes d'équilibrage, de chargement, de lavage et d'élution, cette séquence d'étapes pouvant s'effectuer en partie par lots. Les paramètres déterminés dans de petites préparations, de préférence plusieurs en parallèle, donnent des indications sur les conditions chromatographiques qui permettent de purifier une biomolécule donnée de manière optimale par chromatographie sur colonne, y compris le cas échéant à grande échelle.

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