C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/135, 195/78,
C07K 14/235 (2006.01) A61K 39/10 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1239104
- 1 - Abstract: The invention provides an improved method for the purification of LPF-HA (leucocytosis promoting factor hemagglutinin) on an industrial scale. The method com- prises contacting a LPF-HA-containing solution from the culture media of Bordetella pertussis with a cellulose sulfate gel, a crosslinked polysaccharide sulfate gel, or a polysaccharide gel chemically bound with dextran sulfate, thereby adsorbing the LPF-HA on the gel, and then eluting the LPF-HA from the gel. The method can give a highly purified LPF-HA which does not contain any other proteins, lipids, saccharides, etc. nor undesirable endotoxins, and hence can be used for producing various reagents, medicines and pertussis vaccines.
487035
Ginnaga Akihiro
Kawahara Tetsuo
Mizokami Hiroshi
Nishihara Tsukasa
Sakoh Mitsuo
Juridical Foundation The Chemo-Sero-Therapeutic
Kirby Eades Gale Baker
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