C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/74 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) C07C 231/02 (2006.01)
Patent
CA 2130198
2130198 9321147 PCTABS00027 A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
Cipollo Kent Lee
Dhaon Madhup Krishna
Houbion John Andre
Lundell Edwin Orville
Miller Robert Harold
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Stanko Ronald T.
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