C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2542781
The present invention is in the field of characterization of antibiotic compounds, e.g. such as compounds useful for treating pathogenic infections in mammals and identification of cellular targets thereof. The invention further relates to a method of classifying antibiotic compounds, to methods for determining their modes of action and for identifying new antibiotic targets based on classification schemes comprising clustering according to similarity the biochemical response profiles (e.g. gene expression pattern) of an organism exposed to said compounds, for a period of less than one generation time.
L'invention concerne le domaine de caractérisation de composés antibiotiques, par exemple des composés destinés au traitement d'infections pathogènes chez des mammifères et l'identification de leurs cibles cellulaires. L'invention concerne en outre un procédé permettant de classer des composés antibiotiques, ainsi que des procédés permettant de déterminer leurs modes d'action et d'identifier de nouvelles cibles antibiotiques, sur la base de programmes de classification comprenant le groupage selon la similitude des profils de réponse biochimique (par exemple le motif d'expression génique) d'un organisme exposé auxdits composés pendant une durée n'excédant pas celle d'une génération.
Montijn Roy Christiaan
Schuren Frank Henri Johan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk On
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