Method of detecting carcinoma

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2154251

A method of detecting carcinoma, particularly breast carcinoma, in a test sample of tissue, comprising assessing the expression of cyclins, particularly of cyclin E, or the amplification of cyclin genes, particularly the cyclin E gene, is disclosed. Altered expression of cyclins, such as overproduction of cyclins, particularly cyclin E, or production of alternative cyclin E proteins, as well as deranged appearance of mitotic cyclins during the cell cycle, are indicative of the presence of carcinoma, Amplification of cyclin genes, particularly the cyclin E gene, is also indicative of the presence of carcinoma.

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