C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2154251
A method of detecting carcinoma, particularly breast carcinoma, in a test sample of tissue, comprising assessing the expression of cyclins, particularly of cyclin E, or the amplification of cyclin genes, particularly the cyclin E gene, is disclosed. Altered expression of cyclins, such as overproduction of cyclins, particularly cyclin E, or production of alternative cyclin E proteins, as well as deranged appearance of mitotic cyclins during the cell cycle, are indicative of the presence of carcinoma, Amplification of cyclin genes, particularly the cyclin E gene, is also indicative of the presence of carcinoma.
Keyomarsi Khandan
Pardee Arthur B.
Borden Ladner Gervais Llp
Dana Farber Cancer Institute
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