Method of inducing an enhanced immune response against hiv

Details Method of inducing an enhanced immune response against hiv Method of inducing an enhanced immune response against hiv

A - Human Necessities

61

K

A61K 39/21 (2006.01) C07K 14/16 (2006.01) C12N 15/861 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2478631

An efficient means of inducing an immune response against human immunodeficiency virus ("HIV") utilizing specific prime-boost regimes is disclosed. The specific prime-boost regimes employ a heterologous prime-boost protocol wherein recombinant adenoviral and poxvirus vectors comprising exogenous genetic material encoding a common HIV antigen are administered in that order. Vaccines administered into living vertebrate tissue in accordance with the disclosed regimes, preferably a mammalian host such as a human or a non-human mammal of commercial or domestic veterinary importance, express the HIV-1 antigen (e.g., Gag), inducing a cellular immune response which specifically recognizes HIV-1. It is believed that the disclosed prime/boost regime will offer a prophylactic advantage to previously uninfected individuals and/or provide a therapeutic effect by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV-1 infection.

L'invention concerne des moyens efficaces permettant d'induire une réponse immunitaire contre le virus de l'immunodéficience humaine (VIH) au moyen de régimes de primo-immunisation/rappel. Les régimes de primo-immunisation/rappel spécifiques utilisent un protocole de primo-immunisation/rappel selon lequel des vecteurs adénoviraux et poxviraux recombinants comprenant une matière génétique exogène codant pour un antigène du VIH commun sont administrés dans cet ordre. Les vaccins administrés dans un tissu de vertébré vivant selon les régimes susmentionnés, de préférence chez un hôte mammifère tel qu'un humain ou un mammifère non humain d'importance vétérinaire commerciale ou domestique, expriment l'antigène du VIH-1 (par ex., Gag), ce qui permet d'induire une réponse immunitaire cellulaire reconnaissant spécifiquement le VIH-1. On pense que le régime de primo-immunisation/rappel de l'invention peut offrir un avantage prophylactique aux individus précédemment non infectés et/ou produire un effet thérapeutique par réduction des niveaux de charge virale chez un individu infecté, d'où une prolongation de la phase asymptomatique de l'infection par le VIH-1.

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