G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) C40B 30/04 (2006.01) C40B 80/00 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2591496
This invention provides a method of screening or patterning a biomaterial in terms of their specificities to sugar chains by performing real-time and comprehensive measurement of an interaction between sugar chains and the biomaterial concurrently with a very small amount of the biomaterial without labeling. It Is a method of measuring an interaction between a biomaterial and a sugar chain(s), the method including: bringing a solution containing the biomaterial in contact with a ligand carrier, the ligand carrier including a support whose surface includes a metal, and a ligand conjugate(s) immobilized independently on the surface, the ligand carrier carrying the ligand conjugate(s) in such a manner that 1 to 500 kinds of the ligand conjugate(s) is immobilized per cm2, and each ligand conjugate having a structure in which a sugar chain is bonded with a linker compound having a sulfur atom, and the biomaterial being at least one selected from the groups of proteins, viruses, cells, microorganisms, liposome, and micelles.
Kishimoto Yuko
Nishimura Tomoaki
Okuno Tadaomi
Suda Yasuo
Tsuruta Sachiko
Japan Science And Technology Agency
Macpherson Leslie & Tyerman Llp
Suda Yasuo
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