Method of preferentially inducing the biosynthesis of...

A - Human Necessities – 61 – K

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A61K 31/4745 (2006.01)

Patent

CA 2598437

A method of preferentially inducing IFN-.alpha. biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN- .alpha. biosynthesis in an animal are disclosed.

La présente invention concerne une méthode qui permet d'induire de manière préférentielle la biosynthèse de IFN-a chez un animal et qui consiste à administrer certains composés cycliques imidazo[4,5-c] avec un substituant hydroxyméthyle ou hydroxyéthyle à la position 2 ou des compositions pharmaceutiques contenant les composés. Cette invention concerne également les composés, les intermédiaires et les procédés de préparation et les méthodes d'utilisation de ces composés en tant qu'immunomodulateurs pour traiter des maladies incluant les maladies virales et néoplasiques par induction préférentielle de la biosynthèse de IFN-a chez un animal.

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