Method of preparing phosphodiester conjugates useful for...

Details Method of preparing phosphodiester conjugates useful for... Method of preparing phosphodiester conjugates useful for...

C - Chemistry, Metallurgy

07

F

167/37, 260/460.

C07F 9/10 (2006.01) A61K 9/127 (2006.01) G01N 33/543 (2006.01)

Patent

CA 1340413

A method for producing a phosphodiester-ligand-analyte conjugate, which comprises (a) reacting a polar phospholipid with a ligand to produce a polar phospholipid-ligand composite and (b) reacting the polar phospholipid-ligand composite with an analyte capable of coupling to the ligand of the polar composite, to produce the phosphodiester-ligand-analyte conjugate. The conjugate is subsequently purified, preferably using preparative chromatography, and then incorporated into immunoactive liposomes.

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