Method of purifying a fermentation broth

Details Method of purifying a fermentation broth Method of purifying a fermentation broth

C - Chemistry, Metallurgy

12

P

C12P 17/06 (2006.01) C07D 309/30 (2006.01) C12N 9/99 (2006.01) C12P 17/02 (2006.01)

Patent

CA 2400952

A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.

La présente invention concerne un procédé permettant de purifier des composés de statine à partir d'un jus de fermentation par l'extraction et la cristallisation. Il consiste à soumettre le jus à un traitement préalable qui comprend un prétraitement alcalin et une purification alcaline. Suite au prétraitement, on extrait le composé de statine dans des conditions acides dans un solvant hydrophobe et on le purifie par cristallisation. On effectue une concentration du solvant organique suivie d'une extraction à l'aide d'une base moyenne. On purifie ensuite le composé de statine par cristallisation.

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