Method of purifying nucleoside derivatives

Details Method of purifying nucleoside derivatives Method of purifying nucleoside derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/14 (2006.01) C07H 1/06 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2101281

A crude 2',3'-dideoxynucleoside compound is purified by extracting with an organic solvent, or crystallizing, the 2',3'-dideoxynucleoside compound from a basic aqueous solution having a pH of not less than 12 containing the same. In another embodiment of purification a basic aqueous solution having a pH of not less than 11 of a crude 2',3'-dideoxynucleoside derivative is brought into contact with a nonpolar porous resin, whereby the derivative is adsorbed on the resin, and then the thus adsorbed derivative is desorbed with an aqueous alcoholic solution. 2',3'-Dideoxynucleoside compounds which have utility as anti-AIDS drugs or anti-virus drugs can be isolated and purified in high purity and in high yield from their crude products containing impurities.

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