Method of reducing tissue damage associated with ischemia

Details Method of reducing tissue damage associated with ischemia Method of reducing tissue damage associated with ischemia

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2198536

Disclosed is a pharmaceutical composition for reducing tissue damage resulting from ischemia in a patient which composition comprises an effective amount of a sorbitol dehydrogenase inhibitor, together with a pharmaceutically acceptable diluent or carrier. The sorbitol dehydrogenase inhibitor is for example a substituted pyrimidine compound, such as 4-[4-(N,N-dimethylsulfamoyl)piperazino]-2-hydroxy- methylpyrimidine.

On divulgue une composition pharmaceutique pour réduire les lésions tissulaires causées par l'ischémie chez un malade; la composition comprend une quantité efficace d'un inhibiteur de la sorbitol-déshydrogénase combiné à un diluant ou excipient pharmaceutiquement acceptable. L'inhibiteur de la sorbitol-déshydrogénase est, par exemple, un composé pyrimidique substitué, comme la 4-[4-(N,N-diméthylsulfamoyl)-pipérazino]-2-hydroxy-méthylpyrimidine.

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