C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2556227
The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB 1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
L'invention porte sur un procédé permettant de déterminer la réponse d'un cancer à un traitement par le récepteur du facteur de croissance épidermique (EGFR). Dans une exécution préférée, la présence d'au moins une variance dans le domaine kinasique du gène erbB 1 confère une sensibilité à l'inhibiteur gefitinib de la tyrosine kinase. Ainsi, un essai diagnostique recherchant ces mutations permettra d'administrer le gefitinib, l'erlotinib et d'autres inhibiteurs de la tyrosine kinase tyrosine à ceux des patients les plus susceptibles de répondre au médicament.
Bell Daphne Winifred
Haber Daniel A.
Janne Pasi Antero
Johnson Bruce E.
Lynch Thomas J.
Dana-Farber Cancer Institute Inc.
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
The General Hospital Corporation
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