Method to produce novel polyketides

Details Method to produce novel polyketides Method to produce novel polyketides

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) A61K 31/7042 (2006.01) C07H 17/08 (2006.01) C12N 9/00 (2006.01) C12P 17/18 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2296728

Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of formula (1) or (2), wherein A is a moiety that activates the diketide, and at least one of R1 and R2 is a substituent other than that natively occuring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.

La présente invention concerne des batteries de gènes PKS modifiés produisant de nouveaux polyketides dans un système efficace à l'intérieur d'une cellule hôte ou d'un extrait dépourvu de cellules. Les nouveaux polyketides proviennent de l'incorporation de diketides de la formule (1) ou (2), dans laquelle A est un fragment qui active le diketide, et R?1¿ ou R?2¿ est un substituant autre que celui qui apparaît naturellement dans le diketide normalement traité par la batterie PKS modifiée. On peut également glycosyler les polyketides afin d'obtenir des antibiotiques.

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