Methods and agents for evaluating inflammatory bowel...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/475 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/22 (2006.01) C12N 15/18 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) G01N 33/483 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2682030

The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.

La présente invention concerne des procédés d'évaluation de la maladie du colon irritable (IBD), y compris la maladie de Crohn et la rectocolite hémorragique. L'invention concerne également des procédés permettant de déterminer la susceptibilité d'un patient à développer une IBD, ainsi que des procédés permettant de déterminer le génotype de l'IBD d'un patient. Cette invention inclut en outre des procédés, des polynucléotides, des polypeptides et des anticorps afférents aux variantes présentées du précurseur de type nell 1 (NELL1) et à ses polymorphismes, ainsi qu'au locus 5p13.1, et d'autres gènes présentés ici devant être associés à l'IBD. Ainsi, l'invention concerne des cibles diagnostiques et/ou thérapeutiques pour l'IBD, ainsi que des agents diagnostiques et thérapeutiques pour l'IBD.

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