Methods and compositions based on shiga toxin type 1 protein

Details Methods and compositions based on shiga toxin type 1 protein Methods and compositions based on shiga toxin type 1 protein

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/108 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2646319

The invention is based on the discovery of the epitope in the Stxl protein for the 13C4 antibody. The invention features non-full length Stxl polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-Stxl antibodies specific for the 13C4 epitope of the Stxl protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection ) with a polypeptide that includes the 13C4 epitope or with an anti-Stxl antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stxl in a sample using the antibodies developed using the methods of the invention.

Cette invention repose sur la découverte de l'épitope dans la protéine Stxl pour l'anticorps 13C4. Cette invention concerne des polypeptides Stxl incomplets qui comprennent l'épitope pour l'épitope de l'anticorps monoclonal 13C4. Cette invention concerne également des procédés de production d'anticorps anti-Stxl spécifiques de l'épitope Stxl de la protéine Stxl. Cette invention concerne en outre des méthodes de traitement d'un sujet atteint d'une maladie associée à la toxine de Shiga ou risquant de développer ce type de maladie (telle que le syndrome hémolytique et urémique et les maladies associées à une infection par E. Coli et S. dysenteriae) faisant appel à un polypeptide comprenant l'épitope 13C4 ou à un anticorps anti-Stxl développé au moyen des procédés de cette invention. Cette invention concerne en outre la détection de Stxl dans un échantillon à l'aide des anticorps développés au moyen des procédés de cette invention.

Affiliated with

Also associated with

Rating

Methods and compositions based on shiga toxin type 1 protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions based on shiga toxin type 1 protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions based on shiga toxin type 1 protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1805373