A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01) A61K 31/436 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2748931
Provided are compositions and methods for enhancing immune responses to an antigen. The compositions contain an isolated population of CD8+ T cells and an inhibitor of mammalian target of rapamycin (mTOR). The method for obtaining an enhanced immune response to an antigen in an individual entails administering to the individual the antigen and an inhibitor of mammalian target of rapamycin (mTOR). CD8+ T cells may also be used for adoptive cell transfer (ACT) therapy.
L'invention porte sur des compositions et sur des procédés pour améliorer les réponses immunitaires à un antigène. Les compositions contiennent une population isolée de lymphocytes T CD8+ et un inhibiteur de la cible mammifère de rapamycine (mTOR). Le procédé pour obtenir une réponse immunitaire améliorée à un antigène chez un individu comprend l'administration à l'individu de l'antigène et d'un inhibiteur de la cible mammifère de rapamycine (mTOR). Des lymphocytes T CD8+ peuvent également être utilisés pour une thérapie à transfert adoptif de lymphocytes (ACT).
Kim Hyung
Li Qingsheng
Rao Rajesh
Shrikant Protul
Wang Yanping
Health Research Inc.
Macrae & Co.
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