Methods and compositions for antagonism of rage

Details Methods and compositions for antagonism of rage Methods and compositions for antagonism of rage

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2638755

Antibodies that bind specifically to receptor for advanced glycation end products (RAGE) and RAGE-binding fragments thereof are disclosed. Also disclosed are pharmaceutical compositions comprising such anti-RAGE antibodies and RAGE-binding antibody fragments thereof, and their use for treatment of RAGE related diseases.

La présente invention concerne des anticorps qui se lient spécifiquement au récepteur des produits terminaux avancés de la glycation (RAGE) et des fragments de ces anticorps se liant au RAGE. L'invention concerne également des compositions pharmaceutiques contenant lesdits anticorps anti-RAGE et des fragments desdits anticorps se liant au RAGE, ainsi que leur utilisation pour le traitement de maladies liées au RAGE.

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