C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C12N 9/02 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2446130
Disclosed is a family of P450 monooxygenases, each member of which regioselectively oxidizes avermectin to 4"-keto-avermectin. The P450 monooxgenases find use in methods and formulations for making emamectin from avermectin. Also disclosed are methods for purifying the P450 monooxygenases of the invention, binding agents that specifically bind to the P450 monooxygenases of the invention, and genetically engineered cells that express the P450 monooxygenases of the invention. Also disclosed are ferrodoxins and ferredoxin reductases that are active with the P450 monooxygenases of the invention.
La présente invention concerne une famille de mono-oxygénase P450, dont chaque membre oxyde sélectivement par région l'avermectine en 4''-kéto-avermectine. Ces mono-oxygénases P450 s'utilisent dans des procédés et dans des préparations permettant de fabriquer de l'émamectine à partir de l'avermectine. Cette invention concerne aussi des procédés de purification des mono-oxygénases P450 de l'invention, et des cellules génétiquement modifiées qui expriment les mono-oxygénases P450. Cette invention concerne enfin des ferrédoxines et des ferrédoxines réductases qui sont actives avec les mono-oxygénases P450 de l'invention.
Buckel Thomas Gunter
Hammer Philip Eugene
Hill Dwight Steven
Ligon James Madison
Molnar Istvan
Fetherstonhaugh & Co.
Syngenta Participations Ag
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